Ethanol → 1-Hydroxy-1H-1,2,3-triazole-4-carboxylic Acid
Reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][N:9]([OH:11])[CH:10]=1)=[O:5])C.CCO.O.[OH-].[Li+]>O>[OH:11][N:9]1[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[N:8]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (2.0 g, 13 mmol) and EtOH (25 mL) were combined with a pre-dissolved solution of lithium hydroxide monohydrate (1.6 g, 38.2 mmol) and water (10 mL), and stirred at room temperature for 4 hours. The mixture was partially concentrated and acidified with HCl to cause precipitation. The solid was filtered and dried under vacuum to yield the title compound (1.3 g).
Workup
- concentrationThe mixture was partially concentrated
- customprecipitation
- filtrationThe solid was filtered
- customdried under vacuum
Sources & evidence
- ORD record
- ord-45c8d8295aa741ea8a7a63a1c04c5231
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09120747B2
Reaction notes
Loading…