2-Methoxyethylamine → N-(2-Methoxyethyl)-2-nitroaniline
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].F[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-methoxyethaneamine (3 mL) is added to a solution of 1-fluoro-2-nitrobenzene (400 mg, 2.84 mmol) in ethanol. The reaction may be stirred at room temperature for an appropriate time period (such as overnight) and concentrated. The residue may be purified by any appropriate method including Biotage column chromatography to give N-(2-methoxyethyl)-2-nitroaniline (477 mg).
Workup
- customThe reaction
- concentrationconcentrated
- customThe residue may be purified by any appropriate method
Sources & evidence
- ORD record
- ord-ea8506d4311a492ba5cc7a4ca47f8f31
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09125901B2
Reaction notes
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