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Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

HRID 2275045
Notes
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Reaction equation

HRID 2275045 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:30]=[C:29]([O:31][CH3:32])[C:13]3[N:14]([CH3:28])[C:15]([C:17]4[N:25]([CH2:26][CH3:27])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:33]>C(Cl)Cl>[ClH:33].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:30]=[C:29]([O:31][CH3:32])[C:13]3[N:14]([CH3:28])[C:15]([C:17]4[N:25]([CH2:26][CH3:27])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73052938[(3r)-3-Aminopiperidin-1-Yl][2-(1-Ethyl-1h-Pyrrolo[2,3-B]pyridin-2-Yl)-7-Methoxy-1-Methyl-1h-Benzimidazol-5-Yl]methanone

Product 1

HCID 86340155(R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochlorideYield 94.8%

Reagents, catalysts & solvents 1

HCID 6344Dichloromethane
Solvent

Procedure

(R)-(3-aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone (2.365 g) was dissolved in DCM (6 ml) and HCl (2M in diethyl ether) (2.735 ml, 5.47 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (2.43 g).

Workup

  1. customThe solvent was then removed under nitrogen
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-caef22d374824461a64f308a4985b0d7
Source dataset
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09127003B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes