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Hydrochloric Acid → (R)-N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-methoxypicolinamide hydrochloride

HRID 2275376
Notes
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Reaction equation

HRID 2275376 reaction equation
CO.[F:3][C:4]1[CH:5]=[C:6]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]2[CH:20]=[CH:19][N:18]3[N:21]=[CH:22][C:23]([NH:24][C:25](=[O:34])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[N:27]=4)=[C:17]3[N:16]=2)[CH:7]=[CH:8][CH:9]=1.[ClH:35]>O1CCOCC1>[ClH:35].[F:3][C:4]1[CH:5]=[C:6]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]2[CH:20]=[CH:19][N:18]3[N:21]=[CH:22][C:23]([NH:24][C:25](=[O:34])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[N:27]=4)=[C:17]3[N:16]=2)[CH:7]=[CH:8][CH:9]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 58386272(R)-N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-methoxypicolinamide

Product 1

HCID 67330156(R)-N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-methoxypicolinamide hydrochloride

Reagents, catalysts & solvents 1

HCID 31275
1,4-Dioxane
Solvent

Procedure

To a methanol (1 mL) solution of (R)—N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-methoxypicolinamide (10.1 mg, 0.0234 mmol) was added HCl as a solution is dioxane (30 μL). After 30 minutes, the reaction was concentrated to provide (R)—N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-methoxypicolinamide hydrochloride as a yellow solid.

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-68a3377edf7a443eb803c18430256c5d
Source dataset
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09127013B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes