Sodium Hydroxide → Sodium (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate
Reaction equation
[OH-].[Na+:2].C[O:4][C:5](=[O:22])[CH2:6][C:7]1[N:8]([CH3:21])[C:9](=[O:20])[C:10]([F:19])=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:12]=1>C1COCC1>[F:19][C:10]1[C:9](=[O:20])[N:8]([CH3:21])[C:7]([CH2:6][C:5]([O-:22])=[O:4])=[N:12][C:11]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Na+:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2 ml of 2N sodium hydroxide are added to a solution of 759 mg of (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester in 8 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 695 mg of sodium (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate in the form of a white solid which is used as it is in the next step.