2-Chloroethyl isocyanate → HCID 90427244, compound
Reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]([NH2:6])[CH3:5].[Cl:7][CH2:8][CH2:9][N:10]=[C:11]=[O:12]>C1COCC1>[Cl:7][CH2:8][CH2:9][NH:10][C:11]([NH:6][C@@H:4]([CH3:5])[CH2:3][O:2][CH3:1])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of (S)-1-methoxypropan-2-amine (500 mg, 5.61 mmol) in THF (15 mL) was treated with 2-chloroethylisocyanate (592 mg, 5.61 mmol), stirred at RT overnight, then concentrated to dryness. The residue was treated with toluene and concentrated to dryness (twice) to afford (S)-1-(2-chloroethyl)-3-(1-methoxypropan-2-yl)urea (100% yield assumed) as a white solid which was used without further purification. MS (ESI) m/z: 195.1 (M+H+).
Workup
- concentrationconcentrated to dryness
- additionThe residue was treated with toluene
- concentrationconcentrated to dryness (twice)
Sources & evidence
- ORD record
- ord-d2ddf7a07f8248d79ec25eea7f74d719
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09133183B2
Reaction notes
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