Water → HCID 23156433, compound

HRID 228535

Reaction equation

HRID 228535 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[CH2:23][OH:24].Cl[C:26](Cl)([O:28]C(=O)OC(Cl)(Cl)Cl)Cl.O>C(N(CC)CC)C.C1(C)C=CC=CC=1>[CH3:20][O:19][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][C:15]=1[O:21][CH3:22])[N:12]=[CH:11][CH:10]=[C:9]2[O:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][C:26](=[O:28])[O:24][CH2:23][C:3]=2[CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 94429TriphosgeneHCID 68830546HCID 68830546, compound

Product 1

HCID 23156433HCID 23156433, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 22504574Toluene triethylamineSolvent

Procedure

{2-Amino-5-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}methanol (63 mg) was dissolved in heated triethylamine/toluene (1.2 ml/6 ml) to prepare a solution. Triphosgene (98 mg) was added to the solution and was heated under reflux for 2 min. The reaction solution was cooled to room temperature, water was then added to the reaction solution, and the mixture was extracted with chloroform. The chloroform layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography on silica gel using acetone-chloroform to give the title compound (24 mg, yield 39%).

Workup

  1. customto prepare a solution
  2. temperaturewas heated
  3. temperatureunder reflux for 2 min
  4. extractionthe mixture was extracted with chloroform
  5. washThe chloroform layer was then washed with water and saturated brine
  6. dry with materialwas dried over anhydrous sodium sulfate
  7. customThe solvent was removed
  8. distillationby distillation under the reduced pressure
  9. customthe residue was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-f33e7705410f4bfdb218846039397b48
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Linked notes

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