Hydrochloric Acid → Diethyl (1-methyl-3-oxocyclohexyl)phosphonate
Reaction equation
[CH2:1]([O:3][P:4]([O-:8])[O:5][CH2:6][CH3:7])[CH3:2].[CH3:9][C:10]1[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH:11]=1.Cl>>[CH3:9][C:10]1([P:4]([O:5][CH2:6][CH3:7])(=[O:8])[O:3][CH2:1][CH3:2])[CH2:11][C:12](=[O:16])[CH2:13][CH2:14][CH2:15]1.[CH3:9][C:10]1([P:4]([OH:3])(=[O:5])[OH:8])[CH2:11][C:12](=[O:16])[CH2:13][CH2:14][CH2:15]1Participants
5
Procedure
Diethyl 1-methyl-5-oxocyclohexanephosphonate (B.Pt. 130°-2°/0.8 mm) was prepared by the base catalysed addition of diethylphosphite to 3-methyl-2-cyclohexen-1-one. Hydrolysis of this ester with concentrated HCl gave 1-methyl-5-oxocyclohexanephosphonic acid as a viscous oil.