Piperazine → 1-(4-Methoxy-phenoxy)-3-piperazin-1-yl-propan-2-ol

HRID 2287138

Reaction equation

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:7]([O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[CH:8]1[O:10][CH2:9]1>>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:7][CH:8]([OH:10])[CH2:9][N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 166462,3-Epoxypropyl 4'-methoxyphenyl ether

Product 1

HCID 31593041-(4-Methoxy-phenoxy)-3-piperazin-1-yl-propan-2-olYield 50.7%

Procedure

Following the procedure of part A of Example 1, 9.56 g of piperazine is allowed to react with 10 g of p-methoxyphenyl glycidyl ether to obtain 7.5 g of N-[3-(4-methoxyphenoxy)-2-hydroxypropyl]-piperazine.

Sources & evidence

ORD record: ord-7f71507d747b4c14bed1730a0b3cdaea
Source dataset: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04269838

Linked notes

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