Hydrochloric Acid → HCID 18705827, compound
Reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-:19])=O)=[C:10]([C:14]([O-])=[O:15])[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1.Cl>>[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:29]2[C:14](=[O:15])[C:10]3[CH:11]=[C:12]4[CH2:13][CH:5]([N:4]([CH2:20][CH2:21][CH3:22])[CH2:1][CH2:2][CH3:3])[CH2:6][C:7]4=[CH:8][C:9]=3[C:17]2=[O:19])=[CH:26][CH:25]=1Participants
4
Procedure
Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with 4-chlorobenzylamine (0.17 mL, 1.4 mmol). Purification using silica gel, eluting with 5:1 hexane/acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 102 as a white solid (m.p. 260-261° C.).
Workup
- customPurification
- washeluting with 5:1 hexane/acetone