Hydrochloric Acid → HCID 18705833, compound
Reaction equation
[CH2:1]([N:4]([CH2:20][CH2:21][CH3:22])[CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:17]([O-:19])=O)=[C:10]([C:14]([O-:16])=O)[CH:11]=2)[CH2:6]1)[CH2:2][CH3:3].[CH2:23]([NH2:34])[C:24]1[CH:33]=[CH:32][C:29]([O:30][CH3:31])=[C:26]([O:27][CH3:28])[CH:25]=1.Cl>>[CH3:28][O:27][C:26]1[CH:25]=[C:24]([CH2:23][N:34]2[C:17](=[O:19])[C:9]3[CH:8]=[C:7]4[CH2:6][CH:5]([N:4]([CH2:20][CH2:21][CH3:22])[CH2:1][CH2:2][CH3:3])[CH2:13][C:12]4=[CH:11][C:10]=3[C:14]2=[O:16])[CH:33]=[CH:32][C:29]=1[O:30][CH3:31]Participants
4
Procedure
Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with veratrylamine (0.20 mL, 1.3 mmol). Purification using silica gel, eluting with 3:1 hexane/acetone, afforded an oil that was converted to an HCl salt and recrystallized from hot MeOH/EtOAc to give 106 as a white solid (m.p. 233-235° C.).
Workup
- customPurification
- washeluting with 3:1 hexane/acetone