Sodium Nitrite → HCID 178458288, compound

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[NH2:12])[N:8]=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH2:21][CH3:22])[NH:6][C:5]2=[O:23].[N:24]([O-])=O.[Na+]>Cl.O>[CH2:20]([O:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:7]1[NH:6][C:5](=[O:23])[C:4]2[CH:3]=[C:2]3[NH:1][N:24]=[N:12][C:11]3=[CH:10][C:9]=2[N:8]=1)[CH2:21][CH3:22]

Participants

Procedure

6,7-diamino-2-(2-propoxyphenyl)-4(3H)-quinazolinone (0.15 g, 0.51 mmol) was suspended in 1N HCl (5 mL) and cooled in an ice-methanol bath. A solution of sodium nitrite (0.035 g) in water (1 mL) was added in one portion. The reaction was stirred in an ice bath for 30 minutes, then warmed to room temperature for 90 minutes. The precipitated solid was collected by filtration, washed with water, and dried to afford the title compound as a brown solid (0.42 mmol, 83%): mp dec>260° C.; LRMS [MH+] 308.