Potassium Carbonate → Piritetrate

HRID 2290608

Reaction equation

HRID 2290608 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][CH3:10])[N:4]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:18]([O:20][C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=1)=[S:19]>CC(C)=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]([N:9]([CH3:10])[C:18](=[S:19])[O:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 82681O-2-Naphthyl chlorothioformateHCID 70191686-methoxy-N-methylpyridin-2-amine

Product 1

HCID 145908PiritetrateYield 84.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To the mixture of 1.38 g of 2-methoxy-6-methylaminopyridine, which is one of the compounds of this invention, and the same amount of anhydrous potassium carbonate in 20 ml of acetone, 2.23 g of O-2-naphthyl chlorothioformate dissolved in 20 ml of acetone was added under stirring at room temperature. After 30 minutes, the reaction mixture was extracted with benzene, washed with water, dried and recrystallized to give 2.75 g of O-2-naphthyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate.

Workup

  1. additionwas added
  2. extractionthe reaction mixture was extracted with benzene
  3. washwashed with water
  4. customdried
  5. customrecrystallized

Sources & evidence

ORD record
ord-e353faaeb4a345408ac3d62c39eb4382
Source dataset
uspto-grants-1986_10
Patent number
US04617397

Linked notes

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