HCID 12052140, compound → HCID 13883776, compound
Reaction equation
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[N:5]=1)([O-])=O>C1COCC1.[Pd]>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[N:5]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 5-(3-nitropyrazol-1-yl)valeronitrile (9.16 g.) in dry THF (200 ml.) was added 5% w/w palladium on carbon (1.8 g.). The mixture was stirred at 20° under an atmosphere of hydrogen. 3.2 Liters of hydrogen were absorbed over 4 hours. The catalyst was filtered off and the filtrate was evaporated in vacuo to give 5-(3-aminopyrazol-1-yl)valeronitrile as an oil.
Workup
- custom3.2 Liters of hydrogen were absorbed over 4 hours
- filtrationThe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
Sources & evidence
- ORD record
- ord-e1445fdfb2d24f5ab79428792784cf8f
- Source dataset
- uspto-grants-1989_01
- Patent number
- US04795755
Reaction notes
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