Benzene → 2-(2',3'-Difluorophenyl)-5-n-heptyl-1,3-dioxane

HRID 2292434

Reaction equation

HRID 2292434 reaction equation
[CH2:1]([CH:8]([CH2:11][OH:12])[CH2:9][OH:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[F:13][C:14]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]=O.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>C1(C)C=CC=CC=1>[F:13][C:14]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]1[O:10][CH2:9][CH:8]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:11][O:12]1

Participants

6

Reactant 4

HCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 1376642,3-DifluorobenzaldehydeHCID 2255562-Heptylpropane-1,3-diol

Product 1

HCID 214779562-(2',3'-Difluorophenyl)-5-n-heptyl-1,3-dioxane

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Quantities: compound from Example 8 (27 g, 0.155 mol), 2,3-difluorobenzaldehyde (21.5 g, 0.15 mol) and 4-toluenesulphonic acid (100 mg). The experimental procedure was as described in Example 11 except using dry benzene instead of dry toluene.

Sources & evidence

ORD record
ord-b99c5f95dc184a2fb258b66852360779
Source dataset
uspto-grants-1997_11
Patent number
US05683623

Linked notes

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