Hydrochloric Acid → 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride

HRID 2294009

Reaction equation

HRID 2294009 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1.[ClH:26]>C(O)C>[ClH:26].[ClH:26].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 98623392-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine

Product 1

HCID 214737112-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochlorideYield 94.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

Workup

  1. customthe residue was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-aa119e3e72dc4c73b0141cc73f0aba92
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Linked notes

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