Hydrochloric Acid → 5-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride

HRID 2294039Notes

Reaction equation

HRID 2294039 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[ClH:24]>CO>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[C:17]([NH2:23])=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736195-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine

Product 1

HCID 214736185-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochlorideYield 105.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.23 g (0.00073 mol) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.84 ml (0.00293 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from methanol/diethyl ether. 0.27 g (96%) of 5-[4-(4-methoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:2.3) was obtained as white crystals; m.p. 215°-216°.

Workup

  1. customrecrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-c7d476bda2394c02a6f3f9a7f7daf958
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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