HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Hydrochloric Acid → 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide hydrochloride

HRID 2294155
Notes
Print preview

Reaction equation

HRID 2294155 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:28]=[CH:27][CH:26]=[CH:25][C:19]=3[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:10][CH2:9]2)=[C:4]([O:29][CH3:30])[CH:3]=1.[ClH:31]>C(Cl)Cl.CO>[ClH:31].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:28]=[CH:27][CH:26]=[CH:25][C:19]=3[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:12][CH2:13]2)=[C:4]([O:29][CH3:30])[CH:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 214734832-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide

Product 1

HCID 214734852-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344Dichloromethane
Solvent

Procedure

The 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide (0.19 g, 0.40 mmol) was dissolved in methylene chloride and the solution was treated with excess hydrochloric acid in methanol and concentrated to dryness. The residue was triturated with ethyl acetate and dried to give 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N -dimethylnicotinamide hydrochloride. Anal.: Calcd. for C22H30 BrN5O2.(HCl)2.H2O: C, 46.96; H, 6.37; N, 11.60%; Found: C, 46.56H, 6.37; N, 11.60%.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was triturated with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-aa7790bc74c049e599b1cf733a5b6a02
Source dataset
uspto-grants-1997_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05688795

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes