Aluminium lithium hydride → 3-(8-Phenyloctyloxy)-2-hydroxypropylamine

HRID 2294333

Reaction equation

HRID 2294333 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH:17]([OH:22])[CH2:18][N:19]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH:17]([OH:22])[CH2:18][NH2:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 214747133-(8-Phenyloctyloxy)-2-hydroxypropylazide

Product 1

HCID 214747293-(8-Phenyloctyloxy)-2-hydroxypropylamineYield 88.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in Preparation 13 was repeated, except that 2.6 g of 3-(8-phenyloctyloxy)-2-hydroxypropylazide (Prepared as described in Preparation 65), 0.65 g of lithium aluminum hydride and 80 ml of anhydrous tetrahydrofuran were used, to give 2.11 g of the title compound, melting at 50° C. to 54° C.

Workup

  1. customA procedure similar to that described in Preparation 13

Sources & evidence

ORD record
ord-28d42f0748f2475fa50735ed7cb36052
Source dataset
uspto-grants-1997_11
Patent number
US05688823

Linked notes

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