2-Hexanol → 2-Hexyl 5-amino-4-oxopentanoate Hydrochloride

Reaction equation

[CH3:1][CH:2]([OH:7])[CH2:3][CH2:4][CH2:5][CH3:6].[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15]>>[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14]([O:7][CH:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH3:6])=[O:15]

Participants

Reactant 2

HCID 122972-Hexanol

HCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 574382502-Hexyl 5-amino-4-oxopentanoate Hydrochloride

Procedure

From 2-hexanol (6.0 ml) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 70° C. The reaction was complete after ca. 4 h. The yield was 1.0 g (66%).

Workup

customat 70° C

Sources & evidence

ORD record: ord-04145c0dc8b14eb98a5e2f1794b514c5
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563819B1

Reaction notes

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