Benzophenone imine → 5-Bromo-N-(diphenylmethylene)-2-thiazolamine

HRID 229745

Reaction equation

HRID 229745 reaction equation
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.[Br:16][C:17]1[S:21][C:20](N)=[N:19][CH:18]=1>ClCCCl>[Br:16][C:17]1[S:21][C:20]([N:14]=[C:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:19][CH:18]=1

Participants

4

Reactant 2

HCID 136809Benzophenone imineHCID 27238485-Bromothiazol-2-amine monohydrobromide

Product 1

HCID 112215925-Bromo-N-(diphenylmethylene)-2-thiazolamineYield 82.9%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

26 g of benzophenone imine are added to 34 g of 5-bromo-1,3-thiazol-2-amine hydrobromide, in suspension in 300 ml of 1,2-dichloroethane. The mixture is kept under reflux for 18 hours. The precipitate formed is filtered and the filtrate is concentrated to give 37.2 g of solid.

Workup

  1. temperatureunder reflux for 18 hours
  2. customThe precipitate formed
  3. filtrationis filtered
  4. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-905f5b86eaf74828a0a1af57bd348d0a
Source dataset
uspto-grants-2009_07
Patent number
US07563903B2

Linked notes

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