2-Chloropropionic acid → N-(3,5-difluorophenyl)alanine

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].Cl[CH:11]([CH3:15])[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C@H:11]([C:12]([OH:14])=[O:13])[CH3:15])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

Reactant 2

HCID 117342-Chloropropionic acid

HCID 965953,5-Difluoroaniline

Product 1

HCID 53936901N-(3,5-difluorophenyl)alanine

Procedure

Using the procedure set forth in U.S. Pat. No. 3,598,859, N-(3,5-difluorophenyl)alanine was prepared using 3,5-difluoroaniline (Aldrich) and 2-chloropropionic acid (Aldrich).

Sources & evidence

ORD record: ord-a898120dd8c1439a9de78e20f19d8c55
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06849650B2

Reaction notes

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