Pyridine → Isobutyl 2-bromopropionate
Reaction equation
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.
Workup
- washwashed with 1N HCl, water, aqueous NaHCO3, brine
- dry with materialdried over magnesium sulfate or sodium sulfate
- customRemoval of the solvents at reduced pressure
Sources & evidence
- ORD record
- ord-3f7d1b842cd34c0a9f136902c629ac0f
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06849650B2
Reaction notes
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