1-Bromo-2-methylpropane → HCID 57762509, compound

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[CH2:15](Br)[CH:16]([CH3:18])[CH3:17].[H-].[Na+]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 65551-Bromo-2-methylpropane

HCID 24758Sodium hydride

HCID 57762548N-(4-iodophenyl)pyrimidin-2-amine

Product 1

HCID 57762509HCID 57762509, compoundYield 93.6%

Procedure

In the same manner as in Reference Example 13, N-(4-iodophenyl)pyrimidin-2-amine (150 mg) and isobutyl bromide (83 mg) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-N-isobutylpyrimidin-2-amine (167 mg).

Sources & evidence

ORD record: ord-8ef5187cf1f24acab65ed043a96e29b5
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07566724B2

Reaction notes

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