Butyl iodide → HCID 17902130, compound

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([CH3:13])[C:7]2([CH3:15])[CH3:14])([O-:3])=[O:2].[I:16][CH2:17][CH2:18][CH2:19][CH3:20]>>[I-:16].[CH2:17]([N+:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[C:7]([CH3:15])([CH3:14])[C:8]=1[CH3:13])[CH2:18][CH2:19][CH3:20]

Participants

Reactant 2

HCID 10962Butyl iodide

HCID 975513H-Indole, 2,3,3-trimethyl-5-nitro-

Product 1

HCID 17902130HCID 17902130, compound

Procedure

5-Nitro-2,3,3-trimethylindole (250 mg, 1.22 mmol) and iodobutane (10 ml, 16.17 g, 87.87 mmol) were mixed and heated to reflux for 16hrs. The solvent was removed and the impure material stored at−20° C. for use in later reactions.

Workup

temperatureheated
temperatureto reflux for 16hrs
customThe solvent was removed
custom20° C.

Sources & evidence

ORD record: ord-0bfeec58765445f6a35d1b465bfbc39c
Source dataset: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06828116B1

Reaction notes

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