2,2,2-Trifluoro-1-(3-nitrophenyl)ethanone oxime → 1-(3-Aminophenyl)-2,2,2-trifluoroethanone oxime
Reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)=[N:4][OH:5]>C(O)C.[Pt]>[NH2:12][C:8]1[CH:7]=[C:6]([C:3](=[N:4][OH:5])[C:2]([F:16])([F:15])[F:1])[CH:11]=[CH:10][CH:9]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 2,2,2-trifluoro-1-(3-nitrophenyl)ethanone oxime (2.34 g) and 5% Pt(S)/C (2340 mg) in ethanol (530 mL) was hydrogenated at 50 psi for 2 hours. The crude reaction mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound (2 g) as an oil which was used in the next step without purification.
Workup
- customThe crude reaction mixture
- filtrationwas filtered
- concentrationthe filtrate was concentrated in vacuo
Sources & evidence
- ORD record
- ord-781754cffd2045d4b7fb88111374373f
- Source dataset
- uspto-grants-2004_12
- Patent number
- US06831080B2
Reaction notes
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