Ammonia → 1-(4-Methoxybenzo[d]thiazol-2-yl)urea

HRID 2308485

Reaction equation

HRID 2308485 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[NH2:13][C:14](N)=[O:15].N>O>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:14]([NH2:13])=[O:15])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 1176UreaHCID 216224-Methoxy-2-aminobenzothiazole

Product 1

HCID 222830361-(4-Methoxybenzo[d]thiazol-2-yl)urea

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-amino-4-methoxy-benzothiazole (330 mg, 1.83 mmol) and urea (1.1 g, 1.83 mmol) were heated together for 1 h at 170° C., with evolution of ammonia. After allowing to cool to r.t., water (10 ml) was added and the mixture was vigorously stirred. The solid was then filtered, washed with water (10 ml) followed by ethanol (10 ml) and dried at 60° C. under vaccum (0.05 mmHg). The title product was afforded as an off-white solid (300 mg, 73% yield), MS: m/e=223 (M+).

Workup

  1. filtrationThe solid was then filtered
  2. washwashed with water (10 ml)
  3. customdried at 60° C. under vaccum (0.05 mmHg)

Sources & evidence

ORD record
ord-96dca3ebb6a04d1898c58741f55975db
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Linked notes

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