Hydrogen Bromide → 106487-34-7
Reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2Participants
3
Procedure
1.55 g of the product of Example 2 in 15 ml of 48% hydrobromic acid were refluxed for 2 hours with stirring under an inert atmosphere. After evaporating to dryness under reduced pressure, crystallizing the oil obtained from ethanol, filtering, washing with ether, drying, and purifying by crystallization from methanol, 1.31 g of 1,3-dihydro-7-hydroxy-4-(1-propyl-3-piperidinyl)-2H-indol-2-one hydrobromide melting at 210° C. were obtained.
Workup
- customAfter evaporating to dryness under reduced pressure
- customcrystallizing the oil
- customobtained from ethanol
- filtrationfiltering
- washwashing with ether
- customdrying