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Ammonium Chloride → 1-Acridinol, 1,2,3,4-tetrahydro-9-(((4-(trifluoromethyl)phenyl)methyl)amino)-

HRID 2309479
Notes
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Reaction equation

HRID 2309479 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[C:21](=[O:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:5][CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[Cl-].[NH4+]>C1COCC1>[F:26][C:2]([F:1])([F:27])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[CH:21]([OH:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:24][CH:25]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 13935143HCID 13935143, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 30256271-Acridinol, 1,2,3,4-tetrahydro-9-(((4-(trifluoromethyl)phenyl)methyl)amino)-Yield 76.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
10 °C

Procedure

In 100 ml of dry THF was dissolved 2.49 g of 3,4-dihydro-9-(4-trifluoromethylbenzylamino)acridin-1(2H)-one. The mechanically stirred solution was cooled under nitrogen to 10° C. and 3.4 ml of 1M LiAlH4 in THF was added dropwise over 10 minutes. After 1/2 hour of stirring, the reaction was complete. It was neutralized with 1 ml of saturated ammonium chloride solution and the resulting salts were filtered. The filtrate was evaporated to a solid which was recrystallized from 1:1 dichloromethane/pentane to yield 1.91 g of solid, mp 174°-176° C.

Workup

  1. filtrationthe resulting salts were filtered
  2. customThe filtrate was evaporated to a solid which
  3. customwas recrystallized from 1:1 dichloromethane/pentane

Sources & evidence

ORD record
ord-e0d197e779934a499dd29c0f1b3c2525
Source dataset
uspto-grants-1987_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04695573

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes