Trifluoroacetic acid → 3-Fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Reaction equation

[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:8][c:9]1[cH:10][c:11]([NH:32][C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[cH:12][cH:13][c:14]1[O:15][c:16]1[c:17]2[c:18]([n:19][cH:20][cH:21]1)[cH:22][c:23]([C:25]1=[CH:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]1)[s:24]2>>[F:8][c:9]1[cH:10][c:11]([NH2:32])[cH:12][cH:13][c:14]1[O:15][c:16]1[c:17]2[c:18]([n:19][cH:20][cH:21]1)[cH:22][c:23]([C:25]1=[CH:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]1)[s:24]2

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 66649226Tert-butyl 3-fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

Product 1

HCID 167179683-Fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)aniline

Sources & evidence

ORD record: ord-3bc71f87870641a9bb3bf7067da72cb0
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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