Hydrochloric Acid → 2-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine

Reaction equation

[C:2](=[O:3])([CH3:4])[NH:5][c:6]1[n:7][c:8]2[n:9][cH:10][cH:11][c:12]([NH:16][c:17]3[c:18]([F:25])[cH:19][c:20]([CH3:24])[c:21]([OH:23])[cH:22]3)[c:13]2[cH:14][cH:15]1.[CH3:27][CH2:28][OH:29].[ClH:1].[ClH:26]>>[NH2:5][c:6]1[n:7][c:8]2[n:9][cH:10][cH:11][c:12]([NH:16][c:17]3[c:18]([F:25])[cH:19][c:20]([CH3:24])[c:21]([OH:23])[cH:22]3)[c:13]2[cH:14][cH:15]1

Participants

Reactant 3

HCID 313Hydrochloric Acid2×

HCID 702Ethanol

HCID 22346429N-[5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridin-2-yl]acetamide

Product 1

HCID 223464762-Amino-5-(2-fluoro-5-hydroxy-4-methylanilino)-1,8-naphthyridine

Sources & evidence

ORD record: ord-400a5575c1bb41079d38c139063b1b5c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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