Tetrahydrofuran → methyl 5-[2-fluoro-4-[(2-fluorophenyl)methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoate

HRID 2313720

Reaction equation

HRID 2313720 reaction equation
[CH2:26]([Li:27])[CH2:28][CH2:29][CH3:30].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:18][N:19]([CH3:20])[CH2:21][CH2:22][N:23]([CH3:24])[CH3:25].[F:1][c:2]1[c:3]([CH2:8][O:9][c:10]2[cH:11][c:12]([F:17])[c:13]([Br:16])[cH:14][cH:15]2)[cH:4][cH:5][cH:6][cH:7]1.[O:31]=[C:32]1[CH2:33][CH2:34][CH:35]([C:44](=[O:45])[O:46][CH3:47])[N:36]1[C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43]>>[F:1][c:2]1[c:3]([CH2:8][O:9][c:10]2[cH:11][c:12]([F:17])[c:13]([C:32](=[O:31])[CH2:33][CH2:34][CH:35]([NH:36][C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[C:44](=[O:45])[O:46][CH3:47])[cH:14][cH:15]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 41759311-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylateHCID 595967064-Bromo-3-fluorophenyl (2-fluorophenyl)methyl etherHCID 178418339Butyllithium

Product 1

HCID 178500418methyl 5-[2-fluoro-4-[(2-fluorophenyl)methoxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoate

Sources & evidence

ORD record
ord-61503ea7ead446e8a5eae3d24d5cce9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Linked notes

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