Ethanone, 1-(2,5-dichlorophenyl)- → 2',5'-Dichloro-3-dimethylaminoacrylophenone

HRID 231498

Reaction equation

HRID 231498 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH:10]=[CH:14][N:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 75587Ethanone, 1-(2,5-dichlorophenyl)-HCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 28062062',5'-Dichloro-3-dimethylaminoacrylophenone

Procedure

A mixture of 31.0 g of 2',5'-dichloroacetophenone and 25 ml of N,N-dimethylformamide dimethyl acetal was heated on a steam bath for 6 hours, then evaporated to dryness in vacuo. The residue was slurried with hexane, filtered, and gave 35.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone as orange crystals, mp 83°-85° C.

Workup

  1. temperaturewas heated on a steam bath for 6 hours
  2. customevaporated to dryness in vacuo
  3. filtrationfiltered

Sources & evidence

ORD record
ord-27d59ec2fd5b4cf2ac7c6f2167b13832
Source dataset
uspto-grants-1989_07
Patent number
US04847256

Linked notes

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