Methanol → 3-chloro-N-(3-hydroxy-4-methylphenyl)benzamide

Reaction equation

[CH3:35][OH:36].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([CH3:24])[c:12]([O:14][C:15](=[O:16])[c:17]3[cH:18][cH:19][cH:20][c:21]([Cl:22])[cH:23]3)[cH:13]2)[cH:25][cH:26][cH:27]1.[Na+:29].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1.[OH-:28]>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([CH3:24])[c:12]([OH:14])[cH:13]2)[cH:25][cH:26][cH:27]1

Participants

Reactant 5

HCID 887Methanol

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 8028Tetrahydrofuran

HCID 672130983-Chloro-benzoic acid 5-(3-chloro-benzoylamino)-2-methyl-phenyl ester

Product 1

HCID 8375333-chloro-N-(3-hydroxy-4-methylphenyl)benzamide

Sources & evidence

ORD record: ord-676f2ff407844fdfa25150630a53fe28
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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