Tricalcium Phosphate → Hydroxylapatite (Ca5(OH)(PO4)3)

HRID 231745

Reaction equation

HRID 231745 reaction equation
[P:1]([O-:5])([O-:4])([O-:3])=[O:2].[Ca+2:6].[P:7]([O-:11])([O-:10])([O-:9])=[O:8].[Ca+2].[Ca+2].[OH-].[Ca+2].[OH-]>>[OH-:2].[O-:9][P:7]([O-:11])([O-:10])=[O:8].[O-:3][P:1]([O-:5])([O-:4])=[O:2].[O-:3][P:1]([O-:5])([O-:4])=[O:2].[Ca+2:6].[Ca+2:6].[Ca+2:6].[Ca+2:6].[Ca+2:6]

Participants

3

Reactant 2

HCID 24456Tricalcium PhosphateHCID 6093208Calcium Hydroxide

Product 1

HCID 14781Hydroxylapatite (Ca5(OH)(PO4)3)

Procedure

Generally, the present invention provides a process for obtaining hydroxylapatite by blending dilute aqueous solutions, preferably solutions that are near saturation, of monobasic calcium phosphate (monocal) and calcium hydroxide, followed by separation (e.g. centrifugation), drying, and sintering of the precipitate at 700-1100°C. for about 5-30 minutes to obtain hydroxylapatite having close to the theoretical Ca/P ratio. Thus, in one form of the present invention, a dilute aqueous solution of monobasic calcium phosphate (monocal) is brought into contact with a dilute aqueous solution of calcium hydroxide, in carefully metered proportions, to obtain the amorphous hydroxylapatite precipitate.

Workup

  1. customfollowed by separation (e.g. centrifugation)
  2. customdrying

Sources & evidence

ORD record
ord-f015b138670a4cc0ae11750e4d758c10
Source dataset
uspto-grants-1989_07
Patent number
US04849193

Linked notes

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