Imidazole → HCID 10058334, compound
Reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>O1CCCC1>[N:11]1([C:2]2[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=2)[CH:15]=[CH:14][N:13]=[CH:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In anhydrous tetrahydrofuran, 159 mg of 2-chloro-4-methoxy-6-methylpyrimidine was substituted with 68 mg of imidazole. The reaction mixture was treated according to the Procedure of Example 5 to yield 97 mg of 2-(1-imidazolyl)-4-methoxy-6-methylpyrimidine, recrystallized from n-hexane, having a melting point of 53°-54° C.
Workup
- additionThe reaction mixture was treated
Sources & evidence
- ORD record
- ord-ab19f8767a0c4551ae71325587412845
- Source dataset
- uspto-grants-1989_07
- Patent number
- US04849424
Reaction notes
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