5-Bromo-2-chloropyrimidine → 2-Chloro-5-(3-thienyl)pyrimidine

Reaction equation

[Cl:1][C:2]1[N:7]=[CH:6][C:5](Br)=[CH:4][N:3]=1.[S:9]1[CH:13]=[CH:12][C:11]([Sn](CCCC)(CCCC)CCCC)=[CH:10]1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:11]2[CH:12]=[CH:13][S:9][CH:10]=2)=[CH:4][N:3]=1

Participants

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidine

HCID 10959689Stannane, tributyl-3-thienyl-

Product 1

HCID 123565892-Chloro-5-(3-thienyl)pyrimidine

Procedure

2-Chloro-5-bromopyrimidine and 3-thienyltributyltin are treated in the same manner as in Example 190 to give 2-chloro-5-(3-thienyl)pyrimidine.

Sources & evidence

ORD record: ord-1e36bdd34f9c40229a1193bb06a3ce85
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728706

Reaction notes

Loading…