Sodium Ion → 3-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)phenylamine

Reaction equation

[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:28][CH3:29])[c:7]([O:26][CH3:27])[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([NH:18][C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[cH:15][cH:16][cH:17]2)[n:11]1.[Na+:38].[OH-:37].[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:28][CH3:29])[c:7]([O:26][CH3:27])[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([NH2:18])[cH:15][cH:16][cH:17]2)[n:11]1

Participants

Reactant 4

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 6422Trifluoroacetic acid

HCID 86650315t-Butyl [3-(2-chloro-6,7-dimethoxyquinazolin-4-yl)phenyl]carbamate

Product 1

HCID 576095393-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)phenylamine

Sources & evidence

ORD record: ord-533508273c5847bb9106af9449ee3f0e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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