Ammonia → 5-iodo-2-pyrrolidin-1-yl-1H-benzimidazole

Reaction equation

[Br:1][c:2]1[cH:3][c:4]2[c:5]([nH:6][c:7]([N:9]3[CH2:10][CH2:11][CH2:12][CH2:13]3)[n:8]2)[cH:14][cH:15]1.[CH2:26]1[O:27][CH2:28][CH2:29][O:30][CH2:31]1.[Cu:24][I:25].[I-:16].[NH2:18][CH2:19][CH2:20][NH2:21].[NH3:22].[Na+:17].[OH2:23]>>[c:2]1([I:16])[cH:3][c:4]2[c:5]([nH:6][c:7]([N:9]3[CH2:10][CH2:11][CH2:12][CH2:13]3)[n:8]2)[cH:14][cH:15]1

Participants

Reactant 8

HCID 222Ammonia

HCID 923Sodium Ion

HCID 962Water

HCID 3301Ethylenediamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 30165Iodide Ion

HCID 312751,4-Dioxane

HCID 178419330HCID 178419330, compound

Product 1

HCID 1785065395-iodo-2-pyrrolidin-1-yl-1H-benzimidazole

Sources & evidence

ORD record: ord-ab24ecc96bdf41b3bba436ddf864ec91
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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