Phosphate → 2-Amino-5-tert-butyl-benzothiazole-6-thiol
Reaction equation
[C:1]([C:5]1[C:6]([S:15]C#N)=[CH:7][C:8]2[S:12][C:11]([NH2:13])=[N:10][C:9]=2[CH:14]=1)([CH3:4])([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[NH2:13][C:11]1[S:12][C:8]2[CH:7]=[C:6]([SH:15])[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:14][C:9]=2[N:10]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared according to General Method 14 using 5-tert-butyl-6-thiocyanato-benzothiazol-2-yl-amine (Example L-1; 8 g, 30 mmol), dithiothreitol (18.7 g, 121 mmol), EtOH (200 mL), and phosphate buffer (50 mL). MS (APCI): 239 (M+H).
Sources & evidence
- ORD record
- ord-cbb2200b505743f89d88f8471e6e0c7a
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06852711B2
Reaction notes
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