Aminoacetaldehyde dimethyl acetal → HCID 178495966, compound
Reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]([CH2:7][C:8](=[NH:12])OCC)=[CH:3]1.[CH3:13][O:14][CH:15]([O:18][CH3:19])[CH2:16][NH2:17]>COCCOC>[ClH:1].[CH3:13][O:14][CH:15]([O:18][CH3:19])[CH2:16][NH:17][C:8](=[NH:12])[CH2:7][C:4]1[CH:5]=[CH:6][S:2][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 15 °C
Procedure
A mixture of O-ethyl 3-thiopheneethanimidate hydrochloride (0.14 mol) in 1,2-dimethoxyethane (150 ml) was stirred at 15° C. 2,2-dimethoxyethanamine (0.14 mol) was added portionwise and the mixture was stirred overnight. The mixture was evaporated, yielding N-(2,2-dimethoxyethyl)-3-thiopheneethanimidamide monohydrochloride (interm. 13).
Workup
- stirringthe mixture was stirred overnight
- customThe mixture was evaporated
Sources & evidence
- ORD record
- ord-97a9d938517046e1a774f2b9c91c7706
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05595988
Reaction notes
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