Trifluoroacetic acid → 4-(Carboxymethyloxy)-4'-cyano-biphenyl

HRID 234979

Reaction equation

HRID 234979 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 640094Tert-butyl [(4'-cyanobiphenyl-4-yl)oxy]acetate

Product 1

HCID 432431004-(Carboxymethyloxy)-4'-cyano-biphenyl

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

32.9 g of 4-(tert.butyloxycarbonylmethyloxy)-4'-cyano-biphenyl dissolved in 250 ml of methylene chloride is mixed slowly with 137 ml of trifluoroacetic acid. After stirring for 3 hours, the reaction mixture is evaporated to dryness and the solid residue is triturated with water.

Workup

  1. customthe reaction mixture is evaporated to dryness
  2. customthe solid residue is triturated with water

Sources & evidence

ORD record
ord-2647d34b6ed04ee28679791fce90860a
Source dataset
uspto-grants-1997_01
Patent number
US05597825

Linked notes

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