Methanol → Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

HRID 2352037

Reaction equation

HRID 2352037 reaction equation
[CH:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12.[CH3:12]O>Cl>[CH:1]1([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12

Participants

4

Reactant 2

HCID 887MethanolHCID 127951052,3-Dihydro-1h-pyrrolizine-1-carboxylic acid

Product 1

HCID 12795075Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is dissolved in methanol containing a small amount of concentrated hydrochloric acid. The resulting solution is heated to reflux, and then cooled. The title compound is isolated by rotary evaporation of the solvent under reduced pressure, and may be purified by chromatography on silica gel with hexane/ethyl acetate as eluent.

Workup

  1. temperatureThe resulting solution is heated
  2. temperatureto reflux
  3. temperaturecooled

Sources & evidence

ORD record
ord-586d422b14554575a5537722250183b1
Source dataset
uspto-grants-1989_10
Patent number
US04874871

Linked notes

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