Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 235213

Reaction equation

HRID 235213 reaction equation
[CH3:1][C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.C[Si](C)(C)CCOCOCCCCCCCCCCCCCCCC(O)=O.[CH:53]1([N:59]=[C:60]=[N:61][CH:62]2[CH2:67][CH2:66][CH2:65]CC2)CCCCC1>O1CCCC1>[CH3:1][N:59]([C:60]1[CH:65]=[CH:66][CH:67]=[CH:62][N:61]=1)[CH3:53]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 11268547CID 11268547HCID 1903299516-[(2-Trimethylsilylethoxy)methoxy]hexadecanoic acid

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 121 mg of radicicol, 470 mg of 16-[(2-trimethylsilylethoxy)methoxy]hexadecanoic acid, 7 ml of dry tetrahydrofuran, 240 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 481 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-54986dcb837047f3bcb5034468dedfd1
Source dataset
uspto-grants-1997_01
Patent number
US05597846

Linked notes

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