Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 235215Notes

Reaction equation

HRID 235215 reaction equation
[CH3:1][C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.O1C=CC=C1C=CC(O)=O.[CH:36]1([N:42]=[C:43]=[N:44][CH:45]2[CH2:50][CH2:49][CH2:48]CC2)CCCCC1>O1CCCC1>[CH3:1][N:42]([C:43]1[CH:48]=[CH:49][CH:50]=[CH:45][N:44]=1)[CH3:36]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 10876Furylacrylic acidHCID 11268547CID 11268547

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 500 mg of radicicol, 568 mg of 2-furanacrylic acid, 15 ml of dry tetrahydrofuran, 707 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 746 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-e49686f2024a42e78a6b8cd48cd94c25
Source dataset
uspto-grants-1997_01
Patent number
US05597846

Reaction notes

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