Morpholine → 4-{2-Chloro-6-[(phenylsulfonyl)methyl]pyrimidin-4-yl}morpholine

2,4-dichloro-6-[(phenylsulfonyl)methyl]pyrimidine (6 g, 19.8 mmol) was dissolved in DCM (50 mL) and stirred (under nitrogen) at −5° C. Triethylamine (3.06 mL, 21.8 mmol) was added to give a clear brown solution. Morpholine (1.65 mL, 19.8 mmol) was dissolved in DCM and added dropwise keeping the reaction below −5° C. The cooling bath was then removed and the reaction mixture stirred at room temperature for 1 hour. The reaction mixture was then washed with water (50 mL), dried over magnesium sulphate, filtered and concentrated in vacuo. The crude material was chromatographed on silica, eluting with 0-50% ethyl acetate in DCM to give the desired material as a white solid (4 g).

1. customto give a clear brown solution
2. additionadded dropwise
3. customthe reaction below −5° C
4. customThe cooling bath was then removed
5. stirringthe reaction mixture stirred at room temperature for 1 hour
6. washThe reaction mixture was then washed with water (50 mL)
7. dry with materialdried over magnesium sulphate
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customThe crude material was chromatographed on silica
11. washeluting with 0-50% ethyl acetate in DCM

ORD record

ord-ae827812c6604e2c915909b3334990b7

Source dataset

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07750003B2