Hydrochloric Acid → HCID 68440751, compound
Reaction equation
Cl.[Br:2][C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]>O1CCOCC1>[Br:2][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
10% Aq. hydrochloric acid (2.5 ml) was added to a solution of 2-bromo-4-acetoxy-5-methoxy-N-acetyl-benzylamine 2 (0.45 g, 1.66 mmol) in dioxane (15 ml) and the mixture was refluxed for 2 hours, then cooled and the solvent was concentrated under vacuum and the residue was basified with 10% aq. NaOH. The resulting solid was collected by filtration, washed with cold water and dried to furnish the title compound as white solid in quantitative yield.
Workup
- temperaturethe mixture was refluxed for 2 hours
- temperaturecooled
- concentrationthe solvent was concentrated under vacuum
- filtrationThe resulting solid was collected by filtration
- washwashed with cold water
- customdried
Sources & evidence
- ORD record
- ord-a92d7690c2324249b7d4963110fb0e4e
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07750049B2
Reaction notes
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