Hydrochloric Acid → 2-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

HRID 2358448

Reaction equation

HRID 2358448 reaction equation
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:5])C.Cl>CCO.[OH-].[Na+]>[CH3:16][O:15][C:11]1[CH:10]=[C:9]([CH:7]2[CH2:8][CH:6]2[C:4]([OH:5])=[O:3])[CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19358490Cyclopropanecarboxylic acid, 2-(3-methoxyphenyl)-, ethyl ester

Product 1

HCID 139722332-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

The crude 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester is dissolved in 30 ml EtOH and 15 ml 1N NaOH. After stirring over night, the reaction mixture is acidified with 1N HCl and extracted with diethyl ether. After removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is obtained. This 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification.

Workup

  1. extractionextracted with diethyl ether
  2. customAfter removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid
  3. customis obtained
  4. customThis 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification

Sources & evidence

ORD record
ord-115159adedc34e79819ccca64391392a
Source dataset
uspto-grants-2010_07
Patent number
US07763728B2

Linked notes

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