Cyclohexanecarbonyl chloride → N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamide

Reaction equation

Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[CH:16]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([C:22]([NH:10][CH2:9][C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 3

HCID 75938Cyclohexanecarbonyl chloride

HCID 516892Sodium Bicarbonate

HCID 132261382-Amino-1-(furan-2-yl)ethan-1-one hydrochloride

Product 1

HCID 13773128N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamideYield 91.5%

Procedure

5.0 g of (2-furylcarbonyl)methylamine hydrochloride, 7.6 g of sodium bicarbonate and 4.8 g of cyclohexylcarbonyl chloride are treated in the same manner as described in Preparation 1-(1). 6.5 g of N-cyclohexylcarbonyl-(2-furylcarbonyl)methylamine are thereby obtained. Yield: 91.5%