Hydrazine hydrate (1:1) → HCID 178478298, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:7](=O)[CH:8]=[CH:9][N:10](C)C)[S:5][CH:6]=1.O.[NH2:15]N>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:7]2[CH:8]=[CH:9][NH:10][N:15]=2)[S:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 1-(4-chloro-2-thienyl)-3-(dimethylamino)prop-2-en-1-one (24.6 mmol) and hydrazine hydrate (49.2 mmol) in 25 mL ethanol was refluxed for 15 h and then allowed to cool to room temperature. The solvent was evaporated under reduced pressure and dried in vacuum to afford 4.5 g (99% yield) 3-(4-chloro-2-thienyl)-1H-pyrazole which was used in the next step without further purification.
Workup
- temperaturewas refluxed for 15 h
- customThe solvent was evaporated under reduced pressure
- customdried in vacuum
Sources & evidence
- ORD record
- ord-c923b7aeb9654404b556b2ec30f11375
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08685974B2
Reaction notes
Loading…